The formation of amyloid plaques and neurofibrillary tangles are thought to contribute to the degradation of the neurons (nerve cells) in the brain and the subsequent symptoms of Alzheimer's disease.
Amyloids are structures of proteins that become folded into a shape that allows many copies of that protein to stick together forming fibrils. The previously healthy proteins lose their normal physiological functions and form fibrous deposits in plaques around cells that disrupt the healthy function of tissues and organs.
Nattokinase is a proteolytic enzyme extracted and purified from a Japanese food called nattō, made from fermented soybeans. Published in the 2009 Journal of Agricultural & Food Chemistry, researchers from the National Taiwan University and Taiwan's Biological Chemistry Institute found the enzyme Nattokinase may help prevent the plaque build-up in certain parts of our brain. The research team noted, "This discovery of Nattokinase as an enzyme can be safely consumed orally to break apart or degrade amyloid fibrils which lead to useful applications of therapy in amyloid-related diseases".
Serrapeptase is a proteolytic enzyme derived originally from the digestive tract of silk worms. Published in the July 2013 medical journal “Human and Experimental Toxicology” researchers concluded “The present results support our hypothesis that the oral administration of proteolytic enzymes, Serrapeptase and/or NattoKinase, would have an effective role in modulating certain factors characterizing Alzheimer’s Disease. Thus, these enzymes may have a therapeutic application in the treatment of Alzheimer’s Disease.”
DHA is an omega-3 fatty acid most abundantly found in the brain that is thought to be crucial to its function. However, the brain does not produce DHA. The adult brain gets it through food, supplementation or DHA produced by the liver. Published in the 2012 journal Applied Physiology, Nutrition and Metabolism, researchers found that memory cells in the hippocampus could communicate better with each other and better relay messages when DHA levels in that region of the brain were higher.
Research published in the August 8th 2016 issue of JAMA Neurology supports the neuroprotectant effects of docosahexaenoic acid (DHA) in the aging brain. The study revealed higher serum DHA levels were associated with less cerebral amyloidosis, better memory scores, and less regional brain atrophy. Dr. Joseph F. Quinn, MD, (Department of Neurology, Oregon Health and Science University, Portland) has stated “DHA is the most abundant polyunsaturated fatty acid in the brain, playing an important structural role in synapses while also modulating a number of signaling pathways.”
Kyolic Curcumin (Kyolic) contains Curcumin and Aged Garlic Extract. Curcumin is an anti-inflammatory flavonoid compound that is the principal curcuminoid of the Indian spice turmeric. Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects.
Researchers from the Johns Hopkins University School of Medicine, Baltimore found that a cumulative number of midlife vascular risk factors were associated with elevated brain amyloid. Relationships between vascular risk factors and brain amyloid did not differ by race. However late-life vascular risk factors were not associated with late-life brain amyloid deposition.
Aged Garlic Extract has numerous cardioprotective effects, including preventing or improving atherosclerosis, high cholesterol, and high blood pressure. It also has beneficial effects on reducing the progression rates of calcium deposits in the coronary arteries, which is indicative of atherosclerotic plaque throughout the body including the brain.
Kyolic Aged Garlic Extract is the best validated form from a clinical study perspective.
A study published in January 27 2016 in Integrated Blood Pressure Control “The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial” suggests Aged Garlic Extract (AGE) is effective in reducing peripheral and central blood pressure in a large proportion of patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. Aged garlic extract was highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment.
Proactive measures are a key factor for protecting the brain and preventing Dementia/Alzheimer’s Disease.
Added caveat about Diet Soda: According to a study published in the April 20, 2017 American Heart Association medical journal “Stroke: “Drinking at least one artificially sweetened beverage daily was associated with almost three times the risk of developing stroke or dementia compared to those who drank artificially sweetened beverages less than once a week.” They also said, “To our knowledge, our study is the first to report an association between daily intake of artificially sweetened soft drink and increased risk of both all-cause dementia and dementia because of Alzheimer’s disease.”
Jane Jansen Holistic Practitioner Tree of Life Wellness Center
Host of Holistic Healthline Radio
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