We all want to be healthy and protecting our DNA and Cells in the body is vitally important.
Glutathione helps prevent damage to cells by neutralizing harmful molecules generated during energy production. Glutathione also plays a role in processing medications and cancer-causing compounds (carcinogens), and building DNA, proteins, and other important cellular components. The body uses antioxidants to “scavenge” free radicals, neutralizing them so they can’t damage the DNA or any other part of the cell. Therefore, GSH is vitally important in the synthesis of DNA and the maintenance DNA, the synthesis of protein and amino acids, so the body can utilize them effectively.
Sometimes large doses of pharmaceuticals such as Tylenol, materials in vaccines and environmental toxins causes the depletion of active glutathione. Acetaminophen (Tylenol) produces a toxic by-product when the liver breaks it down. Normally, this toxin is neutralized by glutathione, but excess acetaminophen may overwhelm GSH stores, allowing the toxin to build up and damage the liver.
Published in the January 16, 2018 issue Journal of Neuroinflammation: In disease states, a reduction in brain glutathione occurs with aging, Parkinson’s disease, and Alzheimer’s disease. This provides a biological explanation for our observations of the association between glutathione and cognition.
So What is Glutathione?
Glutathione (GSH) is essential to good health and is known as “The Mother of All Antioxidants” and “The Master of the Immune System”. It is able to prevent damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals.
It is essential in protecting cells from oxidization and activates enzymes vital for the removal of all toxic build up at the cellular level. One unique thing about glutathione is that the body is able to make it in the liver, which is not true of most antioxidants.
Research shows that active glutathione (GSH) also primes white cells such as natural killer (NK) and T cells, your body’s front-line infection fighters. GSH-enhanced T cells are able to produce more infection-fighting substances, controlling both bacterial and viral infections. One clinical trial in particular found that GSH doubled NK cells’ ability to be cytotoxic (kill invaders) after just six months of use.
Glutathione controls when inflammation increases or decreases as needed, by instructing and influencing our immune white cells. This is a completely separate mechanism from its antioxidant properties. Re-balancing GSH levels is important as it reduces chronic inflammation and restores immune function.
GSH can attach itself, like sticky flypaper, so its intended object cannot escape and is removed from the body. GSH is our body’s natural scavenger, knows what is normal and belongs and what does not.
Glutathione boosts white blood cell production to fight infection, particularly the T-cells, which are called lymphocytes. T-cells are at the core of our immunity, and tailor the body’s immune response to pathogens, viral and bacterial infections or anything the cells recognize as being invasive.
A study published in the February 21st 2020 International Journal of Molecular Sciences states, “It has been shown that glutathione is an important molecular switch for the immune system. Furthermore, GSH affects the production of most inflammatory cytokines and is required to maintain adequate interferon (IFN)-γ production by dendritic cells. Based on these data, Dröge and Breitkreutz claimed that the immune system is highly affected by the level of GSH in the body.”
A study published in the July 16th 2020 journal Antioxidants suggests, “A common denominator in all conditions associated with COVID-19 appears to be the impaired redox homeostasis responsible for reactive oxygen species (ROS) accumulation; therefore, levels of glutathione (GSH), the key anti-oxidant guardian in all tissues, could be critical in extinguishing the exacerbated inflammation that triggers organ failure in COVID-19. Drawing on evidence from literature that demonstrates the reduced levels of GSH in the main conditions clinically associated with severe disease, we highlight the relevance of restoring GSH levels in the attempt to protect the most vulnerable subjects from severe symptoms of COVID-19. Finally, we discuss the current data about the feasibility of increasing GSH levels, which could be used to prevent and subdue the disease.” The researchers concluded, “Several pieces of evidence reported in our biochemical analysis suggest that low levels of GSH could be one of the major causes of the excessive inflammatory response linked to severe COVID-19 symptoms and indicate that increasing body GSH could reduce the number of symptomatic patients. Future clinical studies investigating the levels of GSH in COVID-19 patients may be the starting point to explore this possibility.”
A study published September 16th 2000 European Respiratory Journal shows, “Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance, a major cause of cell damage. Alterations in alveolar and lung GSH metabolism are widely recognized as a central feature of many inflammatory lung diseases such as idiopathic pulmonary fibrosis, acute respiratory distress syndrome, cystic fibrosis and asthma. The imbalance and/or genetic variation in antioxidant gamma-GCS and pro-inflammatory versus antioxidant genes in response to oxidative stress and inflammation in some individuals may render them more susceptible to lung inflammation. Knowledge of the mechanisms of GSH regulation and balance between the release and expression of pro- and anti-inflammatory mediators could lead to the development of novel therapies based on the pharmacological manipulation of the production as well as gene transfer of this important antioxidant in lung inflammation and injury. The role of glutathione in oxidant-mediated susceptibility/tolerance, gamma-glutamylcysteine synthetase genetic susceptibility and the potential therapeutic role of glutathione and its precursors in protecting against lung oxidant stress, inflammation and injury.”
Unfortunately taking glutathione as a supplement does not work! Then how can you increase glutathione levels in the body effectively.
Taking glutathione as a supplement has unfortunately been proven to be not effective. One study gave healthy people 500 milligrams twice a day for a month, however due to the digestive process they were unable to raise the glutathione level in the blood.
In 1995, award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists at the University of Tartu, Estonia isolated this distinctive probiotic strain. ME-3 is considered by scientists as a "complete glutathione system" due to its ability to produce glutathione in the human body via three different mechanisms. The unique strain ME-3 is proven to stimulate glutathione production naturally in the human body and works as a glutathione-activating agent.
REG’ACTIV - ESSENTIAL ME-3 : Essential ME-3® provides in one single capsule more than 8 billion micro-encapsulated bacteria. Essential ME-3® can be taken for a short treatment course as well as for long periods of time. Ingredients: maltodextrine, Lactobacillus fermentum ME-3®, magnesium salts of fatty acids (anti-caking agent). Vegetable capsule (hydroxypropylmethylcellulose).
Directions: Take 1 capsule daily, 30 minutes before a meal is best, however it can be taken with a meal as well, or as directed by a health care professional.
For more information about: REG’ACTIV Essential ME-3 Go to Essentialformulas.com
As always it is best to treat any serious health problem through an appointment with your Holistic Practitioner to get specific dosages of supplements and to take into account the rest of your health concerns as to what is most appropriate for you. Office or Telephone Appointments are available at the Tree of Life Wellness Center (508-336-4242).
Jane Jansen, Holistic Practitioner
Host of Holistic Healthline Radio