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Jane’s Blog The Many Benefits of MSM

Posted by Jane Jansen on

MSM or Methylsulfonylmethane, is a naturally occurring compound in foods such as fresh vegetables, meat, and dairy products. MSM provides a source of natural sulfur, which plays a role in many of the body’s processes without any toxicity. MSM, plays an important role in making collagen and glucosamine, both of which are vital for healthy bones and joints, and in the production of immunoglobulins, which help your immune system. There are some people who are sensitive to MSM and will experience digestive discomfort. Introducing it slowly in low doses usually will avoid this. People with psoriasis or psoriatic arthritis should not take MSM as it can exacerbate their symptoms.

Many of MSM’s benefits have links to its anti-inflammatory action. Inflammation is a factor in many health conditions, including arthritis, allergies, skin conditions and cancer. By reducing inflammation, MSM may be able to reduce or eliminate certain symptoms.

As a supplement it is most well-known for connective tissue repair including skin, ligaments, tendons, muscle and cartilage. Many people use MSM for arthritis, joint inflammation, rheumatoid arthritis, bursitis, tendonitis, musculoskeletal pain, torn rotator cuff, torn meniscus, scleroderma, scar tissue, stretch marks, hair loss, wrinkles, protection against sun/wind burn, and accelerated wound / burn healing.

Most people don’t know MSM is beneficial in the prevention and treatment of many Cancers, including Breast, Prostate and Colon.

There are numerous medical studies validating the benefits and safety of MSM for patients with breast cancer, even those taking Tamoxifen.

A South Korean study focusing on the role of MSM affecting growth factors associated with breast cancer identifies MSM to have multiple targets, both in vitro and in vivo, including STAT3, STAT5b, IGF-1R and VEGF, confirming the ability of MSM to suppress tumor initiation, growth and metastasis in a dose dependent manner. The expression of triple negative hormone receptors is also down regulated by MSM. In a xenograft model the mice showed inhibited tumor cell migration and suppressed tumor growth in a dose dependent manner when receiving MSM as part of their drinking water at nul, three or five percent MSM weight over volume. The authors strongly recommend MSM as a trial drug for treating breast cancers because of its multi-targeting mechanism.

PLoS One. 2012; 7(4): e33361.  Published online 2012 Apr 2.

Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways

The researchers concluded “This confirmed the ability of MSM to suppress tumor initiation, growth, and metastasis. Based on all these results from our study, we strongly recommend the use of MSM as a trial drug for treating breast cancers because of its multi-targeting mechanism.”

This study demonstrated that MSM substantially decreased the viability of human breast cancer cells in a dose-dependent manner. MSM also suppressed the phosphorylation of STAT3, STAT5b, expression of IGF-1R, HIF-1α, VEGF, BrK, and p-IGF-1R and inhibited triple-negative receptor expression in receptor-positive cell lines. MSM decreased the DNA-binding activities of STAT5b and STAT3, to the target gene promoters in MDA-MB 231 or co-transfected COS-7 cells.

BMC Cancer. 2015; 15: 474.  Published online 2015 Jun 19

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

This study results indicated that this combination therapy of MSM and Tamoxifen inhibited tumor growth and metastasis. Therefore, this drug combination may have a synergistic and powerful anticancer effect against breast cancer.

A study was released for “The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts” Janus kinase (Jak), signal transducer and activator of transcription (STAT), and insulin-like growth factor (IGF) are the major genes overexpressed in breast cancer.

Environ Toxicol Pharmacol

 2018 Dec;64:101-111. Epub 2018 Oct 10.

Methylsulfonylmethane (Organic Sulfur) Induces Apoptosis and Decreases Invasiveness of Prostate Cancer Cells

A major challenge in the management of prostate cancer (PC) is to limit tumor growth and metastases. Targeted therapies applying natural compounds might be potentially useful in PC treatment. Methylsulfonylmethane (MSM), also known as organic sulfur, is a dietary supplement used for various clinical purposes, mostly known for its anti-inflammatory properties. Therefore, we decided to evaluate the effect of MSM on PC cells LNCaP, PC3 and DU-145 which represent different in vitro models of PC. We observed that MSM decreases the viability and invasiveness of PC cells through the induction of apoptosis and cell cycle arrest in the G0/G1 cell cycle phase. Moreover, MSM in a low dose (200 mM) is able to reduce the migration and invasion of PC cells. Considering the low overall body toxicity and insignificant side effects of MSM, its apoptosis-inducing properties might be used in PC treatment in the future.

Int J Mol Sci . 2016 Jul 15;17(7):1123.

Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells

Methylsulfonylmethane (MSM) is an organic sulfur-containing compound which has been used as a dietary supplement for osteoarthritis. MSM has been shown to reduce oxidative stress and inflammation, as well as exhibit apoptotic or anti-apoptotic effects depending on the cell type or activating stimuli. However, there are still a lot of unknowns about the mechanisms of actions of MSM. In this study, MSM was tested on colon cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis revealed that MSM inhibited cell viability and increased apoptotic markers in both HCT-116 p53 +/+ and HCT-116 p53 -/- colon cancer cells. Increased poly (ADP-ribose) polymerase (PARP) fragmentation and caspase-3 activity by MSM also supported these findings. MSM also modulated the expression of various apoptosis-related genes and proteins. Moreover, MSM was found to increase c-Jun N-terminal kinases (JNK) phosphorylation in both cell lines, dose-dependently. In conclusion, our results show for the first time that MSM induces apoptosis in HCT-116 colon cancer cells regardless of their p53 status. Since p53 is defective in >50% of tumors, the ability of MSM to induce apoptosis independently of p53 may offer an advantage in anti-tumor therapy. Moreover, the remarkable effect of MSM on Bim, an apoptotic protein, also suggests its potential use as a novel chemotherapeutic agent for Bim-targeted anti-cancer therapies.

MSM has so many benefits particularly as we age! Consider including it as part of your daily nutrition routine.

If you would like to make an appointment for specific guidance for your health call 508-336-4242. Telephone and in-office appointments are available Monday through Saturday.

Jane Jansen   Holistic Practitioner Tree of Life Wellness Center

 Host Holistic Healthline Radio


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