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Jane's Blog Alzheimer’s Disease and Glutathione Levels

Posted by Jane Jansen on

Alzheimer’s is a devastating and very complicated disease that medical scientists are doing ongoing research trying to understand how and why it occurs.

As people age the potential for developing Alzheimer’s is very scary with just cause . More than 5 million Americans have Alzheimer’s disease and every 66 seconds someone in the USA develops the disease.  It is a disease that destroys the brain and it is one of the most common causes of dementia. One in three seniors dies with Alzheimer’s or some form of dementia.

According to the Alzheimer’s Association, “Alzheimer’s Disease is a specific type of dementia caused when high levels of certain proteins inside and outside brain cells make it hard for brain cells to stay healthy and to communicate with each other. This leads to the loss of connections between nerve cells, and eventually to the death of nerve cells and loss of brain tissue.”

Most neurologists say Alzheimer's disease is not reversible. One thing everyone agrees on is there are no quick fixes!

Knowing the contributing factors impairing one’s memory is essential to successful prevention as well as treatment.

According to the National Institute on Aging, “Memory loss can happen at any age and for a number of complex reasons.”

They state "The healthy human brain contains tens of billions of neurons—specialized cells that process and transmit information via electrical and chemical signals. They send messages between different parts of the brain, and from the brain to the muscles and organs of the body. Alzheimer's Disease disrupts this communication among neurons, resulting in loss of function and cell death. Damage is widespread, as many neurons stop functioning, lose connections with other neurons, and die. ... At first, Alzheimer's disease typically destroys neurons and their connections in parts of the brain involved in memory, including the entorhinal cortex and hippocampus.

Sleep Apnea is linked to forgetfulness and sometimes dementia because oxygen delivery to the brain is interrupted several hundred times during the night.

The FDA says many drugs can affect memory, including:  sleeping pills, antihistamines, anti-anxiety medications, antidepressants, pain medications, statin drugs used for lowering cholesterol, diabetes medication such as metformin and acid inhibitors such as omeprazole and prilosec.

Acid inhibitors, poor eating habits, digestive disorders and gastric bypass are leading causes of nutritional deficiency to the body and brain, which increases memory loss. Vitamin B12, and B6 are essential for normal nerve function. Lack of minerals, electrolytes, good fats like DHA and proteins can also contribute to memory problems. Even mild dehydration can alter a person's mood, energy level, and ability to think clearly, according to many studies.

Research published in the February 2014 Journal of Alzheimer's Disease (AD) pathology is oxidative stress. AD-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (GSH). The researchers found there is a growing recognition of the involvement of GSH in etiopathogenesis of AD. GSH may well emerge as a linchpin in AD pathogenesis and open new avenues for AD diagnostics as well as targeted therapeutics.

New research published in the January 31st 2018 journal Oxidative Medicine and Cellular Longevity revealed the reduction in GSH has been detected selectively in the brain regions affected by AD pathology, such as frontal cortex and hippocampus, but not in the cerebellum, and correlated with the extent of cognitive impairments, assessed with Mini-Mental State Examination (MMSE) and clinical dementia rate (CDR) scores. The study said "Interestingly, the magnitude of the changes in the glutathione redox cycle seems to correspond with the disease severity. The data suggested that oxidative stress is an early factor in AD pathogenesis that can lead to mitochondrial dysfunction, cell signaling impairments, and increased production of amyloid β (Aβ) peptides.

Glutathione (GSH)  also known as “The Mother of All Antioxidants” and “The Master of the Immune System”. According to numerous studies, glutathione is a powerful regenerator of immune cells and is easily the most important agent in keeping the body detoxified and healthy. GSH is vitally important in the synthesis of DNA and the maintenance DNA, the synthesis of protein and amino acids, so the body can utilize them effectively. In addition, it is essential in protecting cells from oxidization and activates enzymes vital for the removal of all toxic build up at the cellular level.

The question is how to elevate glutathione levels in the body effectively. Taking glutathione as a supplement has unfortunately been proven to be not effective. One study gave healthy people 500 milligrams twice a day for a month, however due to the digestive process they were unable to raise the glutathione level in the blood.

In 1995, award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists at the University of Tartu, Estonia isolated this distinctive probiotic strain. ME-3 is considered by scientists as a "complete glutathione system" due to its ability to produce glutathione in the human body via three different mechanisms. The unique strain ME-3 in  is proven to stimulate glutathione production naturally in the human body and works as a glutathione-activating agent via three different mechanisms.

Reg´Activ DETOX & LIVER HEALTH™* pairs ME-3 with additional, more familiar liver health nutrients. Many herbal and nutritive approaches to supporting liver health work well on the glutathione system. Consequently, they all complement ME-3’s activities: 1. L-selenothionine (easy-to-digest selenium) – Promotes healthy levels of the enzyme glutathione peroxidase, which supports liver tissue health* 2. L-methionine & N-Acetyl-cysteine – Act as glutathione precursors* 3. Milk thistle extract (Silymarin) – Supports production of super antioxidant enzymes in the liver*

Reg´Activ IMMUNE & VITALITY* pairs ME-3 with additional more familiar immune system nutrients: 1. L-Carnitine tartrate – Supports healthy energy levels* 2. Essential B vitamins – Additional support for healthy energy and metabolism* 3. Vitamin C – Well-known support for a healthy immune system*

For more information about ME-3 and Reg'Active products go to

Treating Alzheimer’s disease continues to be challenging for the medical community. However the more medical studies focus on understanding the development of this terrible disease, the closer to effective preventative measures and treatments will become available. In the meantime we should all strive to protect brain function by implementing healthier lifestyles, eliminating neuro-toxins, and focus on giving the brain proper nourishment.

Telephone & In-Office appointments are available at the Tree of Life Wellness Center, call 508-336-4242.

Jane Jansen Holistic Practitioner Tree of Life Wellness Center

Host Holistic Healthline Radio


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