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The Sugar Cancer Connection

Posted by Jane Jansen on

I recently received a call from a wonderful listener to our radio program Holistic Healthline. She was very interested in the information Dr. Jansen presented at the beginning of one show regarding the sugar – cancer connection and requested it be posted on my blog for a family member. So here is some of that monolog, as well as additional information.

According to Wikipedia: Nobel laureate Otto Heinrich Warburg in 1924 hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g. adenosine tryphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis). Warburg reported a fundamental difference between normal and cancerous cells to be the ratio of glycolysis to respiration; this observation is also known as the Warburg Effect.

Cancer is caused by mutations and altered gene expression, in a process called malignant transformation resulting in an uncontrolled growth of cells. The metabolic differences observed by Warburg adapts cancer cells to the hypoxic (oxygen-deficient) conditions inside solid tumors, and results largely from the same mutations in oncogenes and tumor suppressor genes that cause the other abnormal characteristics of cancer cells. Therefore, the metabolic change observed by Warburg is not so much the cause of cancer, as he claimed, but rather, it is one of the characteristic effects of cancer-causing mutations.

Warburg articulated his hypothesis in a paper entitled The Prime Cause and Prevention of Cancer which he presented in lecture at the meeting of the Nobel-Laureates on June 30, 1966. Put in his own words, "the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.”

As early as 1982, scientists around the world realised the importance of sugar molecules for cancer. The American doctor and scientist Georg F. Springer discovered that a certain type of sugar molecules, the truncated O-glycans, were particularly prominent in cancer cells.

Published in the 2013 journal PNAS, Scientists at University of Copenhagen have shown that immature sugar molecules in the form of truncated O-glycans attach to proteins which aid the growth properties of cancer cells. Researcher Dr. Catharina Steentoft stated, " When you know a certain process is important for the development of cancer you can start to consider ways to affect this process in a way that stops the cancer cell from taking advantage of it.”

New research from UCLA, published June 26, 2014 in the journal “Molecular Systems Biology,” demonstrates that glucose starvation --, depriving cancer cells of sugar -- activates a metabolic and signaling amplification loop that leads to cancer cell death as a result of the toxic accumulation of reactive oxygen species, the cell-damaging molecules and ions targeted by antioxidants like vitamin C. Dr. Thomas Graeber, a professor of molecular and medical pharmacology says, "Because cancer cells live on the edge of what is metabolically feasible, this amplifying cycle of oxidative stress ultimately overwhelms and kills the cancer cell. this study provides a framework for rational design of cominatorial therapeutics targeting both metabolism and signaling in cancer." The research team also included collaborators from the department of neurology and the human oncology and pathogenesis program at Memorial Sloan-Kettering Cancer Center and the department of pharmacology at Weill-Cornell Medical College.

In 2012, Dr. Sircus, Director International Medical Varitas Association, found when malignant tissues were cultured in glucose containing mixtures there was a higher consumption of glucose by cancer tissues compared to that of healthy tissues found in both the muscle and liver. The research also shows sugar molecules are not only present but actually aid the growth of the malignant cells. He says, “Sugar and cancer are locked in a death grip, yet oncologists often fail to do what’s necessary to stop their patients from feeding their cancers with sweets.”

PET/CT Scans and Cancer

According to Positron Emission Tomography (PET) and Computed Tomography (CT) imaging have become essential diagnostic tools physicians use to reveal the presence and severity of cancers. PET/CT imaging helps physicians detect cancer, evaluate the extent of disease, select the most appropriate treatments, determine if the therapy is working, and detect any recurrent tumors.

Before a PET/CT scan, the patient receives an intravenous injection of radioactive glucose. Many cancer cells are highly metabolic and rapidly synthesize the radioactive glucose. Information regarding the location of abnormal levels of radioactive glucose obtained from the whole-body PET/CT scan helps physicians effectively pinpoint the source of cancer and detect whether cancer is isolated to one specific area or has spread to other organs.

In other words they use sugar as a medium for transporting the radioactive material because cancer cells are glucose (sugar) gluttons (it's how they get their energy) and suck it up causing cancer cells to light up with radioactive material like a Christmas Tree.

Hopefully you now see the Sugar - Cancer connection and no matter what your Oncologist or Nurse Practitioner says, low sugar diets are crucial to successful Cancer treatments. They just can't ignore the FACTS anymore! If you don't want cancer sticking around stop feeding it.


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